Forskolin: The Unending Research
As of January 2016, new forskolin insight is still becoming widely available to read and research.
Right now, we know forskolin’s effects on the human body work at a immunological, pharmacological and metabolic level that has been taking the American weight watcher communities by storm. Not only is it exerting its allegedly effective weight loss effects, it does so without the harmful risks of synthetically prepared, toxic-laden, cheap weight loss diet pills.
And this is where the secret of Forskolin really unfolds – its all-natural ingredients extracted from the roots of colues forskholii are its prized possession. Its tested by Mother Nature, and proven effective in countless of centuries of Ayurvedic traditional health care practices and is without a doubt nothing less than one of the safest and most effective weight loss preparations ever to grace the modern world. Sound too sweet to be true? So did we, let’s jump into our newly updated research and learn about this natural human body extract hack.
It heralds the return of time-tested age-old remedies that our forefathers have been using to treat a variety of ailments and conditions. Now, science is unlocking those secrets for the benefit of the modern man.
To get to know Forskolin is to learn something about the plant Indian Coleus, scientifically named Coleus forskohli or Plectranthus barbatus. A native to Southeast Aisa and the Indian subcontinent, Coleus forskohli has been used for hundreds of years by traditional folk healers. Indian Coleus is a principal element in Ayurvedic health practices especially used in the management of spasmodic pain, heart diseases, painful urination or dysuria, and convulsions or seizures. The Indian Coleus has also been widely used in Brazilian homes as a remedy for digestion-related problems particularly those related to the function of the liver. Most Brazilian homes make an Indian Coleus infusion as treatment for hangovers and excessive fat in the diet.
These anecdotal pieces of evidence have spurred the scientific community into carefully studying the chemical composition of the Indian Coleus leading to the discovery of Forskolin as its primary active ingredient in the 1970s. Molecular biochemistry has revealed that Forskolin is a type of diterpene that is known as Labdane. Diterpenes are scientifically regarded as important compounds necessary for the production of phytol, retinal, and retinol which serves in a variety of anti-inflammatory and anti-microbial purposes.
Recent studies have shown Forskolin’ s effects on the breakdown of fat as well as the mobilization of fatty acids from the body. This is the basis of the move to reintroduce Forskolin as an effective and safe weight loss preparation. Its effects on cellular processes, particularly the mitigation of the inflammatory response, have led scientists to believe that Forskolin might have scientific basis for its ancient use on the management of a host of inflammatory conditions.
Let’s move on to the foundational coleus forskohlii scientific findings and start understanding as much as we can in laymen terms. Unfortunately much of the information available online is hit or miss, but a few research-backed and properly-cited reviews that discuss the safety and side effects of forskolin supplementation should be a noteworthy cause for credible sources.
To further research the dynamics of everything it purportedly provides as a plant extract, let’s continue.
Scientific Basis of Forskolin Action
As Forskolin is a Labdane diterpene, its cellular effects is closely associated to its action on cyclic adenosine monophosphate or cyclic-AMP through the activation of adenylate cyclase.
Cyclic adenosine monophosphate is an important cellular messenger that acts in a variety of functions. Primarily, cAMP has been shown to play an important role in the movement of the hormonal effects of adrenaline and glucagon across the cell membrane. cAMP activates the various cellular enzymes in order to facilitate the transfer of adrenaline and glucagon metabolites.
Cyclic AMP is also known to regulate certain ion channel function, particularly the cyclic nucleotide-gated and hyperpolarization-activated ion channels that are found in the muscles of the heart as well as tissues on the brain.
Specifically, the actions of cyclic adenosine monophosphate include the following:
- Trigger the release of triiodothyronine and thyroxine from the thyroid gland in order to effect metabolic changes particularly in the breakdown of excess body fat for gluconeogenesis and the mobilization of stored glucose for glycogenolysis.
- Enhance the secretion and utilization of insulin by the different cells of the body.
- Induce relaxation of the smooth muscles of the blood vessels to allow for a smoother flow of blood, reduce blood pressure, and relieve excessive workload on the heart muscles.
- Enhance the ability of the body to burn fat in a process known as lipolysis.
Since the effect of Forskolin is in the indirect elevation of cAMP levels through the activation of the adenylate cyclase enzyme, it thus follows that the effects of cyclic AMP on the human body can be essentially taken as the inherent effects of Forskolin.
Perhaps more importantly, Forskolin has been found to be particularly useful when it comes to the activation and stimulation of the body’s many digestive enzymes. This greatly improves or enhances the individual’s ability to digest and absorb the nutrients that are present in the diet. Combined with the action of cAMP on the induction of lipolytic processes, Forskolin thus becomes a very potent, all-natural, weight loss preparation.
And what Marligen’s research team and staff surprisingly stumbled upon was the mere fact that forskolin extract studies are nothing new, as this one dates back all the way to 1992 discussing the “increasing cyclic AMP concentrations to enhance cardiac contractility“.
Putting Forskolin to the Test
With the striking similarities between Forskolin and cyclic adenosine monophosphate, several scientific endeavors have been initiated just to elaborate on the many supposed effects of Forskolin. Generally, Forskolin has been considered to be predominantly useful for the succeeding purposes:
- Losing weight
- Treatment of bladder infections
- Suppression and control of one’s appetite
- Management of allergies
- Alleviation of menstrual cramps and discomfort
- Promotion of sleep and prevention of insomnia
- Management of irritable bowel syndrome, and
- Treatment of infections of the urinary tract
In a 2012 University of Kansas study, Forskolin was shown to be effective in the promotion of a leaner body composition while at the same time increasing the levels of testosterone and bone density among obese men. Half of the study subjects were placed on a 12-week 250 milligram dose of 10% Forskolin extract. The other half were given sugar pills. The study revealed that the subjects who took Forskolin showed reductions in body fat percentages as well as total fat mass while increasing the overall lean body mass.
These findings have thus bolstered the belief that coleus forskohlii can be an effective weight loss activator and stimulator.
Pure Forskolin Extract’s Safety Considerations
While Forskolin may be derived from the natural plant Indian Coleus, its action on cAMP certainly does provide a cause of concern. These side effects are closely related to what cyclic AMP does to the body. Generally, people who are pregnant, who have problems in the cardiovascular system, have bleeding tendencies, and are scheduled to undergo surgical procedures within the next two weeks, should not take Forskolin.
For starters, Forskolin has been primarily used even in ancient times to use menstrual irregularities as a means to stimulate menstruation. In other societies, Forskolin has also been extensively used as an oral contraceptive. While the scientific community has not yet ascertained the veracity of these effects, it is always generally recommended to be on the cautious side of things.
Forskolin’s effects on the smooth muscles significantly increase the flow of blood. Concurrent administration of drugs that also increase cerebral and coronary blood flow will potentiate the effects of these drugs often leading to lightheadedness or even palpitations. Consequently, by virtue of smooth muscle relaxation, Forskolin inadvertently decreases blood pressure. Should the individual be taking antihypertensives, there is a strong likelihood that hypotension might ensue if Forskolin were to be taken concomitantly.
Forsekolin has also been shown to delay the formation of blood clots. People taking platelet deaggregators and other blood thinning pharmaceutical agents should not take Forskolin. This can adversely and unnecessarily increase the threat of uncontrolled bleeding.
Individuals who may not have any idea of the effects of Forskolin on their existing medical conditions are generally advised to ask ther healthcare professionals.
Forskolin Weight Loss Products
There are a variety of weight loss products that contain Forskolin as the active ingredient. You just have to search the internet and you will be shown a barrage of pure forskolin extract weight loss supplements. Aside from being a multi-faceted herbal extract gone big-time natural supplements, one of the biggest benefits is that it isn’t limited to only one positive benefit or effect. As more research has been done, it’s been proven that coleus forskholii’s root extract forskolin is extremely versatile in what conditions it’s able to treat, enhance or accelerate.
We will continue to monitor and moderate the incoming forskolin literature on science, studies and medical research updates.