Custom-Mixed Genotyping Panels Quote Request

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Please check the boxes next to the SNPs or variants that you would like formulated into one or more custom multiplexes. Generally, multiplexes of 8-12 SNPs are easiest to formulate and give the best results. Please let us know if you have specific requirements regarding the multiplex configuration. We will send you a quotation or contact you if we need additional information.

Check to Include	Original Panel	RefSNP / Desc	Gene (Abr)	AA Change/Desc	Base Change
	Signet™ PG Panel 1	rs1800795	IL6	Promoter Variant	G-174C
	Signet™ PG Panel 1	rs328	LPL	Ser447Stop	C1421G
	Signet™ PG Panel 1	rs1801131	MTHFR	Glu429Ala	A1298C
	Signet™ PG Panel 1	rs4332	ACE	Intronic Variant	C547T
	Signet™ PG Panel 1	rs1801133	MTHFR	Ala222Val	C677T
	Signet™ PG Panel 1	rs5128	APOC3	3'UTR	C3238G
	Signet™ PG Panel 2	rs234706	CBS	Tyr233Tyr	C33T
	Signet™ PG Panel 2	GSTM1del	GSTM1	Whole gene deletion	---
	Signet™ PG Panel 2	GSTT1del	GSTT1	Whole gene deletion	---
	Signet™ PG Panel 2	rs1695	GSTP1	Ile105Val	A342G
	Signet™ PG Panel 2	rs1801282	PPARg	Pro12Ala	C167G
	Signet™ PG Panel 2	rs1805087	MTR	Asp919Gly	A2756G
	Signet™ PG Panel 2	rs1800796	IL6	Promoter Variant	G-573C
	Signet™ PG Panel 2	rs2228570	VDR	creates a new upstream initiation codon	C27823T
	Signet™ PG Panel 2	rs708272	CETP	Intronic Variant	C>T
	Signet™ PG Panel 3	rs1800629	TNFa	Promoter Variant	G-308A
	Signet™ PG Panel 3	rs1801394	MTRR	Ile22Met	A66G
	Signet™ PG Panel 3	rs731236	VDR	3'UTR	C352T
	Signet™ PG Panel 4	rs1544410	VDR	---	A>G
	Signet™ PG Panel 4	rs1799983	eNOS	Glu298Asp	G894T
	Signet™ PG Panel 4	rs1138272 (rs1799811)	GSTP1	Ala114Val	C341T
	Signet™ Obesity Panel 1	rs266729	ADIPOQ	---	?11377C>
	Signet™ Obesity Panel 1	rs1501299	ADIPOQ	Intron	G276T
	Signet™ Obesity Panel 1	rs5030980	AGRP	Ala67Thr	A>G
	Signet™ Obesity Panel 1	rs3792267	CAPN10	Intron	-43G>A
	Signet™ Obesity Panel 1	rs5443	GNB3	Ser275Ser	C825T
	Signet™ Obesity Panel 1	rs1143634	IL-1b	Phe105Phe	T3954C
	Signet™ Obesity Panel 1	rs8192284	IL-6R	Asp358Ala	A1510C
	Signet™ Obesity Panel 1	rs133068	MCHR1	Promoter Variant	C>G
	Signet™ Obesity Panel 1	rs16139	NPY	Leu7Pro	T106C
	Signet™ Obesity Panel 1	rs1801282	PPARgG	Pro12Ala	C167G
	Signet™ Drug Metabolism Panel 1	rs11642466	VKORC1	Intron	A>G
	Signet™ Drug Metabolism Panel 1	rs11642603	VKORC1	Chrom. 16	C>G
	Signet™ Drug Metabolism Panel 1	rs2359612	VKORC1	Intron	A>G
	Signet™ Drug Metabolism Panel 1	rs4889490	VKORC1	3' near gene	G>C
	Signet™ Drug Metabolism Panel 1	rs4889537	VKORC1	3' near gene	G>C
	Signet™ Drug Metabolism Panel 1	rs4889599	VKORC1	5' near gene	C>T
	Signet™ Drug Metabolism Panel 1	rs7194347	VKORC1	Chr 16	A>T
	Signet™ Drug Metabolism Panel 1	rs7294	VKORC1	3' UTR	G>A
	Signet™ Drug Metabolism Panel 1	rs9923231	VKORC1	5' near gene	C>T
	Signet™ Drug Metabolism Panel 1	rs9934438	VKORC1	Intron	G>A
	Signet™ Drug Metabolism Panel 2	rs1057910	CYP2C9	Ile359Leu	A>C
	Signet™ Drug Metabolism Panel 2	rs2860905	CYP2C9	Intron	A>G
	Signet™ Drug Metabolism Panel 2	rs3814637	CYP2C19	5' near gene	C>T
	Signet™ Drug Metabolism Panel 2	rs4917639	CYP2C9	Intron	C>A
	Signet™ Drug Metabolism Panel 2	rs9325473	CYP2C9	Intron	A>G
	Signet™ Drug Metabolism Panel 2	rs9332108	CYP2C9	Intron	T>C
	Signet™ Drug Metabolism Panel 2	rs17882687	CYP2C19	ILle19Leu	A>C
	Signet™ Drug Metabolism Panel 2	rs9332214	CYP2C9	Intron	C>T
	Signet™ Drug Metabolism Panel 3	rs1799809	PROC	5' near gene	A>G
	Signet™ Drug Metabolism Panel 3	rs2069901	PROC	5' near gene	C>T
	Signet™ Drug Metabolism Panel 3	rs2069910	PROC	Intron	G>A
	Signet™ Drug Metabolism Panel 3	rs12714145	GGCX	intron	C>T
	Signet™ Drug Metabolism Panel 4	rs5030838	CYP1A1*2A	Genomic	3801 T>
	Signet™ Drug Metabolism Panel 4	CYP1A1*6	CYP1A1*6	Met331Ile	1636 G>
	Signet™ Drug Metabolism Panel 4	rs4987133	CYP1A1	Ile286Thr	T>C
	Signet™ Drug Metabolism Panel 4	rs2856833	CYP1A1	Phe381Leu	C>A
	Signet™ Drug Metabolism Panel 4	rs1799814	CYP1A1*4	Thr461Asn	2453 C>
	Signet™ Drug Metabolism Panel 4	rs1048943	CYP1A1*2C	Ile462Val	2455 A>
	Signet™ Drug Metabolism Panel 4	rs2278970	CYP1A1	Ala463Gly	C>G
	Signet™ Drug Metabolism Panel 4	rs4986826	AhR	Val570Ile	1768 G>
	Signet™ Drug Metabolism Panel 4	rs1056836	CYP1B1*3	Leu432Val	4326 C>
	Signet™ Drug Metabolism Panel 4	rs1800440	CYP1B1*4	Asn453Ser	4390 A>
	Signet™ Alzheimer's Panel 1	rs405509	APO E	5' near gene	C>A
	Signet™ Alzheimer's Panel 1	rs3745833	GALP	Met72Ile	G>C
	Signet™ Alzheimer's Panel 1	rs8192708	PCK1	Ile267Val	A>G
	Signet™ Alzheimer's Panel 1	rs11622883	Near SERPINA13	---	T>A
	Signet™ Alzheimer's Panel 1	rs1554948	TNK1	Leu27Leu	T>A
	Signet™ Alzheimer's Panel 1	rs157581	TOMM40	Phe113Phe	G>A
	Signet™ Alzheimer's Panel 1	rs4420638	Chromosome 19	---	G>A
	Signet™ Y-SNP Genotyping

Additional Comments or Requirements