Custom-Mixed Genotyping Panels, Genotyping Panels, Signet Customized Genotyping Panels

Marligen’s Signet™ Genotyping Panels are specific multiplexes that detect polymorphisms and gene variants associated with a variety of health and nutritional conditions including heart and bone health, insulin sensitivity, inflammation, obesity and Alzheimer’s disease. These assays have application in nutrigenomics, pharmacogenomics, and toxicogenomics. Download the full list of panels.

Individual assays in Signet™ genotyping panels can be configured into custom-mixed Genotyping Panels. For example, ten SNPs from five different panels can be reconfigured into a single customized panel. Choose as many assays as you like from the full assay list and send the list to Marligen for a custom quotation. Once you have chosen your SNPs or variants, Marligen scientists will reconfigure the panels to your specifications, manufacture reagents, validate performance, and send you a complete package ready for use.

To request a quote or additional information for customized Genotyping Panels please fill out a quote request.

Technology and Protocol

Marligen’s genotyping assays use two different technologies:

Each assay type confers specific benefits and advantages:

Hybridization vs primer extension (print chart)
Protocol for hybridization. (print chart)
Sample data from hybridization assay (print chart)
Protocol for primer extension (print chart)
Sample data from primer extension assay (ex. 1) (ex. 2) (print charts)

Primer Extension Assay Method (supplied with assay kit)	Hybridization Assay Method (supplied with assay kit)
Tag DNA Polymerase 2X PCR Mix Exonuclease I /Shrimp Alkaline Phosphatase 2X Primer Extension Mix Bead Mix Hybridization Buffer Detection Reagent Filter Plates (if required) 9948 Control DNA 9947A ControlDNA Written protocol	Hot-start Taq Polymerase 2X PCR Mix Bead Mix Taq Polymerase Labeling Mix Hybridization Buffer Control DNA Written Protocol
Required but not supplied	Required but not supplied
Platinum tsp genotyping (Invitrogen) PCR Plate or tubes Filter plate manifold with vacuum source	PCR Plates

All of Marligen Signet™ Genotyping Assays are configured to be used in conjunction with the Luminex™ xMAP System for multiplexed analysis. For researchers interested in trying out our assays but do not have access to the Luminex instrumentation or who would prefer to outsource the work, our experienced technical staff also performs Testing Services.

Please inquire for adaptation for use on other platforms.

Signet™ Custom-Mixed Genotyping Panels