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Signet™ Genotyping Panels are specific multiplexes
that detect polymorphisms and gene variants associated with a variety
of health and nutritional conditions including heart and bone health,
antioxidant detoxification function, insulin sensitivity, inflammation,
obesity, Alzheimer’s
disease, blood disorders and oncology. These assays have
applications in nutrigenomics, pharmacogenomics, and toxicogenomics. In addition, we offer lifestyle panels that can test for athletic ability and for the predisposition to male baldness. Download
the full list of panels.
Advantages:
- High-throughput format allows hundreds of samples to be analyzed
in one day
- Excellent allelic discrimination yields >99% accuracy
- Standardized
assay methodology and filter-plate format maximizes reproducibility
- Cost
effective solution for detecting multiple genetic variants in one sample
- Flexible
assay format allows individual assays in Signet™ genotyping
panels to be configured into Customized
Genotyping Panels
Signet™ Genotyping Panels
| Item Name |
Catalog # 384 Tests |
Catalog # *960 Tests |
| Signet™ PG
Panel 1 |
AM100004 (11727-384) |
AM100005 (11727-960) |
|
| Catalog #11727-000 |
| RefSNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
| rs234706 |
CBS |
Tyr233Tyr |
C33T |
| rs1800795 |
IL6 |
Promoter Variant |
G-174C |
| rs328 |
LPL |
Ser447Stop |
C1421G |
| rs1801131 |
MTHFR |
Glu429Ala |
A1298C |
| rs4332 |
ACE |
Intronic Variant |
C547T |
| rs1801133 |
MTHFR |
Ala222Val |
C677T |
| rs5128 |
APOC3 |
3'UTR |
C3238G |
|
|
| Catalog #11728-000 |
| RefSNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
| GSTM1del |
GSTM1 |
Whole gene deletion |
--- |
| GSTT1del |
GSTT1 |
Whole gene deletion |
--- |
| rs1695 |
GSTP1 |
Ile105Val |
A342G |
| rs1801282 |
PPAR |
Pro12Ala |
C167G |
| rs1805087 |
MTR |
Asp919Gly |
A2756G |
| rs1800796 |
IL6 |
Promoter Variant |
G-573C |
| rs2228570 |
VDR |
creates a new upstream initiation codon |
C27823T |
| rs708272 |
CETP |
Intronic Variant |
C>T |
|
|
| Catalog #11729-000 |
| RefSNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
| rs1800629 |
TNFa |
Promoter Variant |
G-308A |
| rs1801394 |
MTRR |
Ile22Met |
A66G |
| rs731236 |
VDR |
3'UTR |
C352T |
|
|
| Catalog #11730-000 |
| RefSNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
| rs1544410 |
VDR |
--- |
A>G |
| rs1799983 |
eNOS |
Glu298Asp |
G894T |
| rs1138272 (rs1799811) |
GSTP1 |
Ala114Val |
C341T |
|
|
| Catalog #11731-000 |
| RefSNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
| rs266729 |
ADIPOQ |
--- |
–11377C>G |
| rs1501299 |
ADIPOQ |
Intron |
G276T |
| rs5030980 |
AGRP |
Ala67Thr |
Ala67Thr |
| rs3792267 |
CAPN10 |
Intron |
-43G>A |
| rs5443 |
GNB3 |
Ser275Ser |
C825T |
| rs1143634 |
IL-1b |
Phe105Phe |
T3954C |
| rs8192284 |
IL-6R |
Asp358Ala |
A1510C |
| rs133068 |
MCHR1 |
Promoter Variant |
C>G |
| rs16139 |
NPY |
Leu7Pro |
T106C |
| rs1801282 |
PPARgG |
Pro12Ala |
C167G |
|
|
| Catalog #11732-000 |
| RefSNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
| rs11642466 |
VKORC1 |
Intron |
A>G |
| rs11642603 |
VKORC1 |
Chrom. 16 |
C>G |
| rs2359612 |
VKORC1 |
Intron |
A>G |
| rs4889490 |
VKORC1 |
3' near gene |
G>C |
| rs4889537 |
VKORC1 |
3' near gene |
G>C |
| rs4889599 |
VKORC1 |
5' near gene |
C>T |
| rs7194347 |
VKORC1 |
Chr 16 |
A>T |
| rs7294 |
VKORC1 |
3' UTR |
G>A |
| rs9923231 |
VKORC1 |
5' near gene |
C>T |
| rs9934438 |
VKORC1 |
Intron |
G>A |
|
|
| Catalog #11733-000 |
| RefSNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
| rs1057910 |
CYP2C9 |
Ile359Leu |
A>C |
| rs2860905 |
CYP2C9 |
Intron |
A>G |
| rs3814637 |
CYP2C19 |
5' near gene |
C>T |
| rs4917639 |
CYP2C9 |
Intron |
C>A |
| rs9325473 |
CYP2C9 |
Intron |
A>G |
| rs9332108 |
CYP2C9 |
Intron |
T>C |
| rs17882687 |
CYP2C19 |
Ile19Leu |
A>C |
| rs9332214 |
CYP2C9 |
Intron |
C>T |
|
|
| Catalog #11734-000 |
| RefSNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
| rs1799809 |
PROC |
5’ near gene |
A>G |
| rs2069901 |
PROC |
5’ near gene |
C>T |
| rs2069910 |
PROC |
Intron |
C>T |
| rs12714145 |
GGCX |
Intron |
C>T |
|
|
| Catalog #11735-000 |
| RefSNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
| rs4646903 |
CYP1A1 |
Genomic |
3801 T>C |
| CYP1A1 |
CYP1A1*6 |
Met331Ile |
1636 G>T |
| rs4987133 |
CYP1A1 |
Ile286Thr |
T>C |
| rs2856833 |
CYP1A1 |
Phe381Leu |
C>A |
| rs1799814 |
CYP1A1 |
Thr461Asn |
2453 C>A |
| rs1048943 |
CYP1A1*2C |
Ile462Val |
2455 A>G |
| rs2278970 |
CYP1A1 |
Ala463Gly |
C>G |
| rs4986826 |
AhR |
Val570Ile |
1768 G>A |
| rs1056836 |
CYP1B1*3 |
Leu432Val |
4326 C>G |
| rs1800440 |
CYP1B1*4 |
Asn453Ser |
4390 A>G |
|
|
| Catalog #11736-000 |
| RefSNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
| rs405509 |
APO E |
5' near gene |
C>A |
| rs3745833 |
GALP |
Met72Ile |
G>C |
| rs8192708 |
PCK1 |
Ile267Val |
A>G |
| rs11622883 |
Near SERPINA13 |
--- |
T>A |
| rs1554948 |
TNK1 |
Leu27Leu |
T>A |
| rs157581 |
TOMM40 |
Phe113Phe |
G>A |
| rs4420638 |
Chromosome 19 |
--- |
G>A |
|
|
| Catalog #11737-000 |
| RefSNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
| rs1799945 |
HFE |
His63Asp |
347C>G |
| rs1800730 |
HFE |
Ser65Cys |
353A>T |
| rs1800562 |
HFE |
Cys282tyr |
1005G>A |
|
|
| Catalog #11738-000 |
| RefSNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
| rs334 |
HBB (HbS) |
Glu6Val |
GAG>GTG |
| rs33930165 |
HBB (HbC) |
Glu6Lys |
GAG>AAG |
| rs33950507 |
HBB (HbE) |
Glu26Lys |
GAG>AAG |
|
|
| Catalog #11740-000 |
| RefSNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
| CHEK2 1100delC |
CHEK2 |
-- |
delC |
| GSTT1del |
GSTT1 |
Whole gene deletion |
-- |
| rs1042522 |
TP53 |
Arg72Pro |
C>G |
| rs1045485 |
CASP8 |
Asp302His |
G>C |
| rs2987983 |
ESR2 |
-- |
-13,950 T>C |
| rs619824 |
CYP17 |
-- |
-15,891 C>A |
| rs7965399 |
IGF1 |
-- |
T>C |
|
|
| Catalog #11751-000 |
| RefSNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
| rs4341 |
ACE |
-- |
Del Alu Rpt |
| rs1815739 |
ACTN3 |
Arg577Stop |
C>T |
| rs11549465 |
HIF-1A |
Pro582Ser |
C>T |
| rs1049434 |
MCT-1 |
Asp490Glu |
A1470T |
| rs1042714 |
ADRB-2 |
Gln27Glu |
G298C |
|
|
| Catalog #11752-000 |
| RefSNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
| GSTM1del |
GSTM1 |
Whole gene deletion |
-- |
| rs1800629 |
TNFα |
Promoter Variant |
G-308A |
| rs1800795 |
IL6 |
Promoter Variant |
G-174C |
| rs1801133 |
MTHFR |
Ala222Val |
C677T |
| rs1801282 |
PPARγ |
Pro12Ala |
C167G |
| rs328 |
LPL |
Ser447Stop |
C1421G |
| rs4341 |
ACE |
--- |
Del Alu Rpt |
| rs4880 (rs1799725) |
SOD2 |
Ala16Val |
T201C |
| rs5128 |
APOC3 |
3'UTR |
C3238G |
| rs731236 |
VDR |
3'UTR |
C352T |
|
|
| Catalog #11753-000 |
| RefSNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
| rs4988235 |
MCM6 |
intron |
intron 13 C/T (-13910 ) |
| rs2395182 |
HLA-DRA (DQA1-201) |
near 3' end |
T>G |
| rs7775228 |
DQB1-202 |
--- |
C>T |
| rs4713586 |
DQ4 |
--- |
C>T |
| rs2187668 |
HLA-DQA1(DQ2.5) |
intron |
G>A |
| rs4639334 |
DQ7 |
--- |
G>A |
| rs7454108 |
DQ8 |
--- |
T>C |
| rs698 |
ADH1C |
Ile349Val |
A>G |
| rs762551 |
CYP1A2 *1F |
intron |
-163A>C |
|
|
| Catalog #11754-000 |
| RefSNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
| Amel |
Amel |
--- |
6 base insertion |
| rs1041668 |
X-chrom |
--- |
C>T |
| rs1160312 |
Chromosome 20 |
--- |
G>A |
| rs1385699 |
EDA2R |
Arg57Lys |
C>T |
| s2180439 |
Chromosome 20 |
--- |
C>T |
| rs6152 |
AR |
Glu213Glu |
G>A |
| rs6625163 |
X-chrom |
Ile349Val |
G>A |
|
|
| Catalog #11755-000 |
| RefSNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
| EPOR |
EPOR |
Try439Stop |
G6002A |
| rs11206244 |
DIO1 |
3' UTR |
C785T aka C802T |
| rs1799983 |
NOS3 |
Glu298Asp |
G894T |
| rs8192678 |
PPARγC1 |
Gly482Ser |
A>G |
| rs12095080 |
DIO1 |
3' UTR |
A1814G akaA1834G |
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*Sizes greater than 960 tests are available. Please contact
us for more details.
Technology and Protocol
All of the above Signet™ Genotyping Assays use the primer
extension method.
|
Components supplied with kit* |
- Taq DNA Polymerase
- 2X PCR Mix
- Exonuclease I /Shrimp Alkaline Phosphatase
- 2X Primer Extension Mix
- Bead Mix
- Hybridization Buffer
- Detection Reagent
- Filter Plates
(if required)
- 9948 Control DNA
- 9947A Control DNA
- Protocol
|
| Required but not supplied |
- Platinum Tsp genotyping (Invitrogen)
- PCR Plate or tubes
- Filter
plate manifold with vacuum source
* A template for data acquisition and data analysis software available
upon request |
The Signet™ Genotyping Assays are configured to be used
in conjunction with the Luminex™ xMAP
System for
multiplexed analysis. For researchers interested in trying out our assays
but do not have access to the Luminex instrumentation or who would prefer
to outsource the work, our experienced technical staff also performs
Testing Services. Please
inquire for adaptation for use on other platforms.
For additional information on any of the following Signet™ Genotyping
Panels, or to obtain pricing for the 960 test kits, please submit a quote
request form or contact us at 866-464-4990.
Request a Genotyping Panel
Quote >>
Order Signet™ Genotyping Panels
For international pricing and orders please contact
one of our international distributors.
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