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Marligen’s Signet™ Genotyping Panels are specific multiplexes
that detect polymorphisms and gene variants associated with a variety
of health and nutritional conditions including heart and bone health, antioxidant
detoxification function, insulin sensitivity, inflammation, obesity and
Alzheimer’s
disease. These assays have application in nutrigenomics, pharmacogenomics,
and toxicogenomics. Download the full list of panels.
To request a quote or additional information for any of the following Signet™ Genotyping
Panels, please fill submit a quote request form or contact us at 866-464-4990.
Signet™ Genotyping Panel
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| Catalog #11727-000 |
| RefSNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
| rs1800795 |
IL6 |
Promoter Variant |
G-174C |
| rs328 |
LPL |
Ser447Stop |
C1421G |
| rs1801131 |
MTHFR |
Glu429Ala |
A1298C |
| rs4332 |
ACE |
Intronic Variant |
C547T |
| rs1801133 |
MTHFR |
Ala222Val |
C677T |
| rs5128 |
APOC3 |
3'UTR |
C3238G |
|
|
| Catalog #11728-000 |
| RefSNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
| rs234706 |
CBS |
Tyr233Tyr |
C33T |
| GSTM1del |
GSTM1 |
Whole gene deletion |
--- |
| GSTT1del |
GSTT1 |
Whole gene deletion |
--- |
| rs1695 |
GSTP1 |
Ile105Val |
A342G |
| rrs1801282 |
PPAR |
Pro12Ala |
C167G |
| rs1805087 |
MTR |
Asp919Gly |
A2756G |
| rs1800796 |
IL6 |
Promoter Variant |
G-573C |
| rs2228570 |
VDR |
creates a new upstream initiation codon |
C27823T |
| rs708272 |
CETP |
Intronic Variant |
C>T |
|
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| Catalog #11729-000 |
| RefSNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
| rs1800629 |
TNFa |
Promoter Variant |
G-308A |
| rs1801394 |
MTRR |
Ile22Met |
A66G |
| rs731236 |
VDR |
3'UTR |
C352T |
|
|
| Catalog #11730-000 |
| RefSNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
| rs1544410 |
VDR |
--- |
A>G |
| rs1799983 |
eNOS |
Glu298Asp |
G894T |
| rs1138272 (rs1799811) |
GSTP1 |
Ala114Val |
C341T |
|
|
| Catalog #11731-000 |
| RefSNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
| rs266729 |
ADIPOQ |
--- |
–11377C>G |
| rs1501299 |
ADIPOQ |
Intron |
G276T |
| rs5030980 |
AGRP |
Ala67Thr |
Ala67Thr |
| rs3792267 |
CAPN10 |
Intron |
-43G>A |
| rs5443 |
GNB3 |
Ser275Ser |
C825T |
| rs1143634 |
IL-1b |
Phe105Phe |
T3954C |
| rs8192284 |
IL-6R |
Asp358Ala |
A1510C |
| rs133068 |
MCHR1 |
Promoter Variant |
C>G |
| rs16139 |
NPY |
Leu7Pro |
T106C |
| rs1801282 |
PPARgG |
Pro12Ala |
C167G |
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| Catalog #11732-000 |
| RefSNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
| rs11642466 |
VKORC1 |
Intron |
A>G |
| rs11642603 |
VKORC1 |
Chrom. 16 |
C>G |
| rs2359612 |
VKORC1 |
Intron |
A>G |
| rs4889490 |
VKORC1 |
3' near gene |
G>C |
| rs4889537 |
VKORC1 |
3' near gene |
G>C |
| rs4889599 |
VKORC1 |
5' near gene |
C>T |
| rs7194347 |
VKORC1 |
Chr 16 |
A>T |
| rs7294 |
VKORC1 |
3' UTR |
G>A |
| rs9923231 |
VKORC1 |
5' near gene |
C>T |
| rs9934438 |
VKORC1 |
Intron |
G>A |
|
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| Catalog #11733-192 |
| RefSNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
| rs1057910 |
CYP2C9 |
Ile359Leu |
A>C |
| rs2860905 |
CYP2C9 |
Intron |
A>G |
| rs3814637 |
CYP2C19 |
5' near gene |
C>T |
| rs4917639 |
CYP2C9 |
Intron |
C>A |
| rs9325473 |
CYP2C9 |
Intron |
A>G |
| rs9332108 |
CYP2C9 |
Intron |
T>C |
| rs17882687 |
CYP2C19 |
ILle19Leu |
A>C |
| rs9332214 |
CYP2C9 |
Intron |
C>T |
|
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| Catalog #11734-192 |
| RefSNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
| rs1799809 |
PROC |
5’ near gene |
A>G |
| rs2069901 |
PROC |
5’ near gene |
C>T |
| rs2069910 |
PROC |
Intron |
C>T |
| rs12714145 |
GGCX |
Intron |
C>T |
|
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| Catalog #11735-192 |
| RefSNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
| rs5030838 |
CYP1A1*2A |
Genomic |
3801 T>C |
| CYP1A1*6 |
CYP1A1*2A |
Met331Ile |
1636 G>T |
| rs4987133 |
CYP1A1 |
Ile286Thr |
T>C |
| rs2856833 |
CYP1A1 |
Phe381Leu |
C>A |
| rs1799814 |
CYP1A1 |
Thr461Asn |
2453 C>A |
| rs1048943 |
CYP1A1*2C |
Ile462Val |
2455 A>G |
| rs2278970 |
CYP1A1 |
Ala463Gly |
C>G |
| rs4986826 |
AhR |
Val570Ile |
1768 G>A |
| rs1056836 |
CYP1B1*3 |
Leu432Val |
4326 C>G |
| rs1800440 |
CYP1B1*4 |
Asn453Ser |
4390 A>G |
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| Catalog #117236-000 |
| RefSNP or Description |
Gene (Abr) |
AA Change/Desc |
Base Change |
| rs405509 |
APO E |
5' near gene |
C>A |
| rs3745833 |
GALP |
Met72Ile |
G>C |
| rs8192708 |
PCK1 |
Ile267Val |
A>G |
| rs11622883 |
Near SERPINA13 |
--- |
T>A |
| rs1554948 |
TNK1 |
Leu27Leu |
T>A |
| rs157581 |
TOMM40 |
Phe113Phe |
G>A |
| rs4420638 |
Chromosome 19 |
--- |
G>A |
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*Sizes greater than 960 tests are available. Please contact
us for more details.
Request a Genotyping Panel Quote >>
Technology and Protocol
All of the above Marligen’s Signet™ Genotyping Assays use the primer
extension method.
Primer Extension Assay Method
(supplied with assay
kit) |
- Tag DNA Polymerase
- 2X PCR Mix
- Exonuclease I /Shrimp Alkaline Phosphatase
- 2X Primer Extension Mix
- Bead Mix
- Hybridization Buffer
- Detection Reagent
- Filter Plates
(if required)
- 9948 Control DNA
- 9947A ControlDNA
- Protocol
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| Required but not supplied |
- Platinum tsp genotyping (Invitrogen)
- PCR Plate or tubes
- Filter
plate manifold with vacuum source
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All of Marligen Signet™ Genotyping Assays are configured to be used
in conjunction with the Luminex™ xMAP
System for
multiplexed analysis. For researchers interested in trying out our assays
but do not have access to the Luminex instrumentation or who would prefer
to outsource the work, our experienced technical staff also performs
Testing Services.
Please inquire for adaptation for
use on other platforms.
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