Protein Phosphorylation Products, SH2 Domains, Phosphoprofiling Tools

Vantage™ microRNA Analysis Products
Transcription Factors/Nuclear Receptor Products
SNP Genotyping Assays
xMAP® Multiplex Assays
Protein Phosphorylation Products
- SH2 domains
PCR/RT-PCR
- First Strand cDNA Synthesis
- PCR Purification Kits
DNA and RNA Purification
DNA Mass Ladders
- DNA Mass Ladders

Marligen offers phosphoprofiling tools that exploit Src homology 2 (SH2) domains for profiling the tyrosine phosphoproteome that are ideal for generating a “snapshot” of the phosphorylation status of the cell.

SH2 Domains

Marligen’s SH2 domains can be used in a variety of applications such as phosphotyrosine profiling, protein-protein and protein-peptide interaction studies, and immunoprecipitation of phosphorylated proteins. These products are valuable in differentiating phosphotyrosine profiles between normal and diseased or treated samples. (Nollau and Mayer 2001 PNAS 98(24) p.13531; Dierck et al. 2006 Nature Methods 3(9) p.737.)

The SH2 domains can be used in many fields of research including signal transduction, proteomics, biomarker discovery, molecular diagnostics, and drug discovery and development.